| Wednesday, September 3, 08:00 - 17:00 | |
| Thursday, September 4, 09:00 - 18:00 | |
| Friday, September 5, 09:00 - 12:15 |
The program will be updated until the conference.
Wednesday September 3 |
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| 08:00-08:45 Registration | ||||||
| 08:45-09:00 Introduction/purpose of the meeting (organizers); Introduction of the keynote speaker | ||||||
| Keynote Speaker: | ||||||
| 09:00- 09:45 | Sir Peter Ratcliffe New Insights into Oxygen Homeostasis? |
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| 09:45- 10:00 | Coffee break | |||||
| Session 1: Metabolite-mediated generation of Malignancy | ||||||
| Chair: Sir Peter Ratcliffe | ||||||
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10:00-10:30 |
Craig Thompson, MD, Memorial Sloan Kettering Cancer Center What oncometabolites have taught us about biology |
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| 10:30-11:00 |
Celeste Simon, PhD, University of Pennsylvania Exploiting tumor metabolism for therapeutic gain |
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| 11:00-11:30 |
Sara-Maria Fendt, Professor. PhD, VIB-KU Leuven Center for Cancer Biology Metabolic rewiring driving metastasis formation |
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| 11:30-12:00 |
Russell Jones, PhD, Chair and professor, Van Andel Research Insitute Metabolic reprogramming of anti-tumor immunity |
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| 12:00-13:00 | Lunch | |||||
| Session 2: Metabolites and Immune Response | ||||||
| Chair: Jorge Ruas | ||||||
| 13:00-13:30 |
Erika Pearce, Professor, Johns Hopkins University Delineating the metabolic signals that direct immune cell differentiation and function |
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13:30-14:00 |
Carl June, MD, The University of Pennsylvania High-Octane CAR T: Tuning Metabolism for Enhanced Persistence and Potency |
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| 14:00-14:30 |
Marcia Haigis, PhD, Harvard Medical School Metabolites in cancer and immunity |
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| 14:30-15:00 | Coffee break | |||||
| 15:00-15:30 |
Luke O’Neill, PhD, Trinity College Dublin How mitochondria control cytokines |
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| 15:30-16:00 |
Randall Johnson, Professor, Karolinska Institutet aKG and glutaric acid: a link between control and catabolism |
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| 16:00-16:30 |
Lydia Lynch, Professor, Princeton University Cytokines as ancient metabolic messengers |
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| 16:30-17:00 |
Marina Kreutz, PhD, University Hospital Regensburg The immunological Warburg effect – a metabolic checkpoint |
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| 17:00-18:00 | Reception, drinks and light snacks in Nobel Forum | |||||
Thursday September 4 |
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| Session 3: Metabolites generated by the Microbiome and by Nutrition | ||||||
| Chair: Mikael Rydén | ||||||
| 09:00-09:30 |
Harry Sokol, PhD, Sorbonne Université Gut Microbiota-derived metabolite and intestinal inflammation |
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| 09:30-10:00 |
Sara Vieira-Silva, Professor. Dr, Johannes Gutenberg University Tracking microbial metabolism in health and disease |
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| 10:00-10:30 |
Max Nieuwdorp, Professor. Dr, Amsterdam UMC Tryptophan metabolites as modulators of immunological tone in autoimmune DM1 |
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| 10:30-10:45 | Coffee break | |||||
| 10:45-11:15 |
Martin Bergö, Professor of Molecular Medicine and Vice President, Karolinska Institutet Oxidative stress, antioxidants, and tumor progression |
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| 11:15-11:45 | Anna Krook, Professor, Karolinska Institutet | |||||
| 12:00-13:00 | Lunch | |||||
| Session 4: Metabolites and energy regulation | ||||||
| Chair: Carolina Hagberg | ||||||
| 13:00-13:30 |
Navdeep Chandel, PhD, Northwestern University Mitochondria signaling in physiology and disease |
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| 13:30-14:00 |
Audrey Carriére, PhD, Restore Lactate as a redox metabolite supporting non shivering thermogenesis. |
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| 14:00-14:30 |
Joshua Rabinowitz, MD. PhD, Princeton University Metabolism in action |
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| 14:30-15:00 |
Matthew Vander Heiden, MD. PhD, MIT Environmental influence on cancer metabolism |
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| 15:00-15:30 | Coffee break | |||||
| Session 5: Metabolites and organismal metabolism | ||||||
| Chair: Anna Krook | ||||||
| 15:30-16:00 |
David James, Professor, The University of Sydney Probing metabolic disease using systems genetics |
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| 16:00-16:30 |
Lydia Finley, PhD, Memorial Sloan Kettering Cancer Center Metabolic control of cell fate decisions |
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| 16:30-17:00 |
Jorge Ruas, Ph.D. University of Michigan Tryptophan / Kynurenine metabolites in metabolism and mental health |
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| 17:00-17:30 |
Mikael Rydén, Professor, Karolinska Institutet Novel insights into the link between metabolites and white adipose tissue function |
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Friday September 5 |
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| Session 6: Metabolites, epigenetics, and post-translational modification | ||||||
| Chair: Randall Johnson | ||||||
| 09:00-09:30 |
Sonia Rocha, Professor, University of Liverpool Mechanisms controlling gene expression in hypoxia |
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| 09:30-10:00 |
Yingming Zhao, Professor, The University of Chicago |
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| 10:00-10:30 |
Christian Frezza, Professor, University Hospital of Cologne, CECAD The role of fumarate hydratase in cancer |
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| 10:30-10:45 | Coffee break | |||||
| 10:45-11:15 |
Edward Chouchani, PhD, Dana-Farber Cancer Institute / HHMI Mass spectrometry and machine learning to identify a cellular cysteine sensor |
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| 11:15-11:45 |
Ralph DeBerardinis, MD/PhD, University of Texas Southwestern Medical Center Metabolic reprogramming and cancer progression in patients |
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| 11:45-11:50 |
Concluding remarks and farewell from the Organisers | |||||
Martin Bergö
Audrey Carrière
Navdeep Chandel
Edward Chouchani
Ralph DeBerardinis
Sarah-Maria Fendt
Lydia Finley
Christian Frezza
Marcia Haigis
David E. James
Randall Johnson
Russell Jones
Carl June
Marina Kreutz
Anna Krook
Lydia Lynch
Claudio Mauro
Max Nieuwdorp
Luke O'Neill
Erika Pearce
Joshua D. Rabinowitz
Sir Peter Ratcliffe
Sonia Rocha
Jorge Ruas
Mikael Rydén
Celeste Simon
Harry Sokol
Craig Thompson
Matthew Vander Heiden
Sara Vieira-Silva
Yingming Zhao