PRELIMINARY PROGRAM

Session topics

• Clinical metabolomics
• Precision medicine
• Computational metabolomics/AI
• Plant metabolomics
• Technical developments in NMR- and MS-based metabolomics

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	Tuesday 30th of January 2024
08.30	Registration
08.50	Welcome
	09:00 - 10:30 Session I: Clinical metabolomics Chair: Gerhard Gröbner
09.00	Keynote speaker 1 Guro Giskeødegård, Norwegian University of Science and Technology, Norway  Decoding the metabolic trajectory of breast cancer: from risk assessment to treatment monitoring and follow-up
09.30	Katia Capuccini, Imperial College London, United Kingdom Direct on-swab metabolic profiling by DESI-MS for monitoring and stratification of live biotherapeutic intervention during pregnancy
09.45	Ida Erngren, Department of Medical Sciences, Uppsala University, Sweden Bile acid metabolism in multiple sclerosis is perturbed and gut microbiota co-metabolism is associated with risks for disease worsening
10.00	Sebastian Löding, Department of Chemistry, Umeå University, Sweden Altered plasma metabolite levels can be detected years before a glioma diagnosis
10.15	Ali Moazzami, Department of Molecular Sciences, Swedish University of Agricultural Sciences,Sweden Distinct human ß-cell line short-term fuel excess detoxification processes revealed by metabolomics and flux analysis
10.30	Break (fika)
	11:00 - 12:15 Session II: Plant metabolomics Chair: Thomas Moritz
11.00	Keynote speaker 2 Young Hae Choi, Leiden University, Netherlands  Exploring the Advantages and Challenges of NMR-Based Chemical Profiling in Medicinal Plant Metabolomics
11.30	Sara Westman, Umeå University, Sweden Identification of candidate genes driving salicinoid diversity in Populus tremula chemotypes: Insight from metabolomic and transcriptomic profiling
11.45	Madhusree Mitra, UPSC Swedish University of Agricultural Sciences, Sweden Understanding the role of cell wall matrix polysaccharides in altering aspen cuticle chemistry by integrating mass spectrometry with multivariate tools
12.00	Jenna Lihavainen, Umeå Plant Science Centre, Sweden Salicylic acid metabolism and signalling coordinate autumn senescence in aspen
12.15	Lunch
	13:30 - 15:45 Session III: Computational metabolomics/AI Chair: Henrik Antti
13.30	Keynote speaker 3 Timothy Ebbels, Imperial College London, UK  Pathway space transformation for metabolomics-focused integration of multi-omics data
14.00	Matthias Mattanovich, University of Copenhagen, Denmark Comparison of approaches to multi-omics data analysis for systems biology: lipolysis in brown adipocytes
14.15	Samuel Bertrand, Nantes Université, France Natural product biosynthesis regulation in microorganisms – what can system biology tells us?
14.30	Break (fika)
15.00	Akshai Parakkal Sreenivasan, Uppsala University, Sweden Forecasting disease transition in multiple sclerosis using conformal prediction
15.15	Edvin Forsgren, Department of Chemistry, Umeå University, Sweden OPLS-HDA - a hierarchical approach for interpretable multiclass-classification
15.30	Raphael Kozlovsky, Lifespin GmbH Enhancing Personal Health Monitoring — Navigating Opportunities and Challenges in NMRbased Metabolomics with Machine Learning
15.45 - 16.45	Poster Session Fika will be served as well
18.30	Conference dinner with entertainment

	Wednesday 31th of January 2024
08.30-08.45	Metabolomics infrastructure in Umeå: SMC, SNC and CASP
	08:45 - 10:00 Session IV: NMR-based metabolomics Chair: Corine Sandström
08.45	Keynote speaker 4 Marine Letertre, University of Nantes, France  Innovative NMR methods to overcome the current limitations of NMR Metabolomics
09.15	Elin Alexandersson, Swedish University of Agricultural Sciences, Sweden Extended Automated Quantification Algorithm (AQuA) for targeted 1H NMR metabolomics of highly complex samples: Application to plant root exudates
09.30	Arianna Cirillo, University of Liege, Belgium How can metabolomics help the follow-up management of kidney transplantation recipients? An untargeted based-metabolomics multiplatform study
09.45	Clare Cannet, Bruker NMR-based Metabolomics: Challenges, implications and clinical research applications
10.00	Break (fika)
	10:30 - 12:00 Session V: Technical developments in MS-based metabolomics Chair: Annika Johansson
10.30	Keynote speaker 5 Daniel Globisch, Uppsala University, Sweden Chemoselective Metabolomics - Unique Chemical Biology Tools to Explore Gut Microbiome Metabolism
11.00	Saira Hameed, The Rosalind Franklin Institute, Harwell, United Kingdom Mass spectrometry imaging of single cells
11.15	Henrik Carlsson, Department of Medical Sciences, Uppsala University, Sweden Untargeted screening of environmental contaminants using LC-HRMS reveals previously unknown associations between PFAS exposure and the human plasma metabolome
11.30	Dan McGill, Rosalind Franklin Institute, Harwell, United Kingdom Non-enzymatic digestion of condensed phase macromolecules using a cold argon plasma
11.45	Andreas Eriksson, Department of Chemistry, Umeå University, Sweden Decoupling time dependence reveals metabolites tied to productivity and cell death in CHO antibody production
12.00	Lunch
	13:00 - 15.20 Session VI: Clinical metabolomics 2/Precision medicine Chair: Elin Chorell
13.00	Keynote speaker 6 Helen Lindqvist, University of Gothenburg Metabolomics as a tool in nutrition research
13.30	Liam Ward, National Board of Forensic Medicine, Sweden Metabolomics in death science: large-scale cause-of-death screening
13.45	Jenny Jakobsson, Department of Medical Sciences, Uppsala University, Sweden Fibromyalgia patients have altered lipid concentrations associated with disease symptom severity, anti-satellite glial cell IgG antibodies, and body mass index
14.00	Kim Kultima, Department of Medical Sciences, Uppsala University, Sweden Serum levels of per- and polyfluorinated substances may alter the disease course in multiple sclerosis – a population-based cohort study
14.15	Break (fika)
14.35	Tova Eurén, Department of Public Health and Clinical Medicine, Umeå University, Sweden Muscle fiber type-specific link between sphingolipid metabolism and insulin sensitivity
14.50	Olena Rzhepishevska, Department of Chemistry, Umeå University, Sweden Biomarkers for transition of latent to active tuberculosis derived from a Swedish biobank cohort may support stratification of patients
15.05	Emilia Johansson, Department of Molecular Biology, Umeå University, Sweden Hedgehog gene regulation by dietary sugar and metabolic regulatory pathways
15.20-15.30	Ending with rewards